If you think that you're too small to make a difference, then you haven't spent a night with a mosquito!
At Drug Discovery for Tropical Diseases (www.ddtd.org), we envision curing malaria, a modern plague, with just one pill. And we’re so close! We are working towards changing the lives of 225 million people affected with malaria and saving the more than 500,000 children lost each year to this preventable disease.
Yes, we can imagine a world in which low income parents don’t have to watch their children die. Yes, we believe we can provide a new drug for 25 cents.
Drug Discovery for Tropical Diseases is a 501c3 non-profit research organization and our team is composed of successful professionals from different pharmaceutical companies (Biogen Idec, Novartis, Roche, Abbott, Vertex, etc...).
Our lead project is to cure malaria with just one pill. In addition, since the current malaria medications are failing due to drug resistance, we want a drug against which the parasite cannot become resistant. We have a compound and ideas that could solve both challenges simultaneously (see www.ddtd.org details) while remaining cheap.
Donors play a critical role: they kindle the fire. Our business model is such that private donors seed the company, while grant awarding bodies and pharmaceutical companies make the subsequent, larger investments. We wish to raise an initial $335,000 (seed money) to generate a solid data package and convince pharmaceutical companies to join the project. We purposely selected a project for which a leading company (Sanofi) could be willing to sponsor clinical trials.
The initial research is relatively cheap, and we are doing our part, but we need your support to make it happen.
Thank you for considering us, and remember:
"We must be the change we wish to see in the world"
Achievements to date
- Created a state-of-the art laboratory.
- Assembled a team of highly successful researchers (Biogen Idec, Novartis, Roche, Pfizer, UC Riverside, etc...).
- Obtained support from Sanofi (clinical data, and desire to help downstream).
- Received donations of greater than $5,000 per individual donors.
- Currently hiring a chemist for this project.
To demonstrate that our drug is not only potent upon injections but also upon oral administration (in mice).
Questions and Answers
Q: How do I make my gift tax-deductible?
A: Donations made through Indiegogo are tax-deductible. You will receive a receipt immediately.
Q: Can I help in a different way?
A: If you have a specific skill you want to share, contact us at firstname.lastname@example.org. In addition, spreading the word is important. Make some noise about our project, and send this information to your friends!
Q: What happens if you don't raise the full amount?
A: Then we will proceed incrementally. The funds will go to make the absolute most critical compounds first, and we will raise money from other sources to test them.
Q: Can you summarize the project, technically speaking?
A: We start from one of the most potent antimalarials ever described, Albitiazolium. Sanofi has obtained encouraging results in humans with this compound (Phase II clinical trials), and is willing to contribute to our project with downstream resources. Notably, Albitiazolium is 10 times more potent than any marketed malaria drug, and, contrary to the current drugs it cures malaria in just one dose (in mice). It is incredibly easy to make, and therefore very inexpensive. For all its qualities, Albitiazolium has also a drawback: it needs to be injected, which is not practical for rural and impoverished areas. Our goal is therefore to convert Albitiazolium into a pill. When swallowed, Albitiazolium does not cross the gut efficiently. We have two technologies that could solve the problem. One technology involves formulations based on biodegradable nanoparticles that stick to the intestinal mucosa and keep the compound in contact with the gut for longer. The second technology involves pro-drugs. Pro-drugs are compounds that are easily absorbed, and then release the desired drug in the blood stream.
Q: Can you give a sense for your budget?
A: Synthesize 60 new antimalarials ($140,000) + test them ($127,000) + project management ($54,000) + miscellaneous ($14,000) = $335,000. A detailed budget will be provided upon request (email us at email@example.com).
Thank you for your support!
Team on This Campaign: