An explorers look at the history and culture of psychoactive plants and compounds, and an examination of how they are currently viewed. Each episode will take an in depth look at the story of a particular substance in a given city, and will then connect that narrative to how the substance is treated there today. The pilot episode focuses on the history of psychedelic mushrooms in Huautla de Jimenez, Mexico, with R. Gordon Wassons exposure to Mazatec curandero rituals, the resulting recreational popularization of mushrooms, and what effect narco-tourism has had on Huautla today.